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What is a risk factor associated with having a child with ASD?

  1. If a father uses antidepressants while trying to conceive

  2. If a mother uses antihistamines during pregnancy

  3. If a mother is over 30 years old

  4. If a father is over 40 years old

The correct answer is: If a father is over 40 years old

Research indicates that advanced paternal age, particularly when a father is over 40 years old, is associated with an increased risk of autism spectrum disorder (ASD) in children. This association is thought to be related to the higher likelihood of genetic mutations in the sperm of older fathers, which can contribute to developmental issues in the offspring such as ASD. Studies have consistently shown that children born to older fathers may have a higher incidence of neurodevelopmental disorders when compared to those born to younger fathers. In contrast, while factors like maternal age and certain medication use can play roles in developmental health, the specific connection of advanced paternal age with increased ASD risk is well-documented and established in research literature.